This article concerns the study of a protictithere from the late Miocene of Axios Valley (Macedonia, Greece). The material was found in the hominoid-bearing mammal locality Ravin de la Pluie (RPl), which is corellated with the late Vallesian, MN 10. The available material, including maxillary and mandibular elements, is described and compared morphologically and metrically with the known Eurasian protictitheres. The small size, the low cusps(-ids) of the teeth, the protocone of the P4, which is in line with the mesial border of the parastyle, the large molars (especially the M2), the small buccal projection of the M1 paracone, the strongly molarized p4, the strong metaconid and large talonid with high entoconid of the m1 separate the RPl protictithere from the known Eurasian protictitheres and allow the erection of a new species, named P. thessalonikensis n. sp. © 2011 Springer-Verlag.